#1M 0 X 10 0 Hal 351 r09 OmniAb ANCHORED SPIN-OFF INVESTOR PRESENTATION D March 2022 DAN LETU T Lutin Sapprently IMPOR 7 THEFTED 2 22-0 Trusse FARHAD THUA 00 W Muni 11 H#2LEGAL DISCLAIMERS About this Presentation This presentation is for informational purposes only to assist interested parties in making their own evaluation with respect to a proposed business combination (the Business Combination) between Avista Public Acquisition Corp. II (APAC) and OmniAb, Inc. (OmniAb), a wholly owned subsidiary of Ligand Pharmaceuticals Incorporated (Ligand), and related transactions, and for no other purpose. The information contained herein does not purport to be all inclusive and no representation or warranty, express or implied, is or will be given by APAC, OmniAb or Ligand or any of their respective affiliates, directors, officers, employees or advisers or any other person as to the accuracy, completeness or reliability of the information contained in this presentation. Forward-Looking Statements This presentation contains forward-looking statements. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "might," "plan," "possible," "potential," "predict," "project," "sho ," "would" and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. All statements other than statements of historical facts contained in this presentation, including statements regarding the expected timing and structure of the proposed transaction, the ability of the parties to complete the proposed transaction, the expected benefits of the proposed transaction, the tax consequences of the proposed transaction, the amount of gross proceeds expected to be available to OmniAb after the closing and giving effect to any redemptions by APAC shareholders, OmniAb's future results of operations and financial position, business strategy and its expectations regarding the application of, and the rate and degree of market acceptance of, the OmniAb technology platform and other technologies, OmniAb's expectations regarding the addressable markets for our technologies, including the growth rate of the markets in which it operates, the potential for and timing of receipt of milestones and royalties under OmniAb's license agreements with partners, are forward-looking statements. These forward-looking statements are not guarantees of future performance, conditions or results, and involve a number of known and unknown risks, uncertainties, assumptions and other important factors, many of which are outside the control of Ligand, OmniAb and APAC, that could cause actual results or outcomes to differ materially from those discussed in the forward-looking statements. Important factors, among others, that may affect actual results or outcomes include, but are not limited to: the risk that the transactions may not be completed in a timely manner or at all, which may adversely affect the price of Ligand's or APAC's securities; the risk that APAC shareholder approval of the proposed transactions is not obtained; the inability to recognize the anticipated benefits of the proposed transactions, which may be affected by, among other things, the amount of funds available in APAC's trust account following any redemptions by APAC's shareholders; the failure to receive certain governmental and regulatory approvals; the occurrence of any event, change or other circumstance that could give rise to the termination of the merger agreement; changes in general economic conditions, including as a result of the COVID-19 pandemic or the conflict between Russia and Ukraine; the outcome of litigation related to or arising out of the proposed transactions, or any adverse developments therein or delays or costs resulting therefrom; the effect of the announcement or pendency of the transactions on Ligand's, OmniAb's or APAC's business relationships, operating results, and businesses generally; the ability to continue to meet Nasdaq's listing standards following the consummation of the proposed transactions; costs related to the proposed transactions; that the price of APAC's or Ligand's securities may be volatile due to a variety of factors, including Ligand's, APAC's or OmniAb's inability to implement their business plans or meet or exceed their financial projections and changes in the combined capital structure; the ability to implement business plans, forecasts, and other expectations after the completion of the proposed transactions, and identify and realize additional opportunities; and the ability of OmniAb to implement its strategic initiatives. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the "Risk Factors" section of APAC's registration statement on Form S-1 (File No. 333-257177), the registration statement on Form S-4, the registration statement on Form 10, the proxy/information statement/prospectus and certain other documents filed or that may be filed by APAC, Ligand or OmniAb from time to time with the SEC following the date hereof. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Ligand, OmniAb and APAC assume no obligation and do not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. Neither Ligand, OmniAb, or APAC gives any assurance that Ligand, OmniAb or APAC will achieve their expectations. This caution is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. 2 Market and Industry Data This presentation also contains estimates and other statistical data made by independent parties and by us relating to market size and growth and other data about the antibody industry. This data involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such estimates. In addition, projections, assumptions, and estimates of OmniAb's future performance and the future performance of the markets in which OmniAb operates are necessarily subject to a high degree of uncertainty and risk. OmniAb#3LEGAL DISCLAIMERS Important Information and Where to Find It In connection with the proposed transaction, OmniAb will file a registration statement on Form 10 registering shares of OmniAb common stock and APAC will file with the SEC a registration statement on Form S-4 registering shares of APAC common stock, warrants and certain equity awards. The Form S-4 to be filed by APAC will include a proxy statement/prospectus in connection with the APAC shareholder vote required in connection with the proposed transaction. The Form 10 to be filed by OmniAb will include the Form S-4 registration statement filed by APAC which will serve as an information statement/prospectus in connection with the spin-off of OmniAb. This communication does not contain all the information that should be considered concerning the Business Combination. This communication is not a substitute for the registration statements that OmniAb and APAC will file with the SEC or any other documents that APAC or OmniAb may file with the SEC or that APAC, Ligand or OmniAb may send to stockholders in connection with the Business Combination. It is not intended to form the basis of any investment decision or any other decision in respect to the Business Combination. APAC's shareholders and Ligand's stockholders and other interested persons are advised to read, when available, the preliminary and definitive registration statements, and documents incorporated by reference therein, as these materials will contain important information about APAC, OmniAb and the Business Combination. The proxy statement/prospectus contained in APAC's registration statement will be mailed to APAC's shareholders as of a record date to be established for voting on the Business Combination. The registration statements, proxy statement/prospectus and other documents (when they are available) will also be available free of charge, at the SEC's website at www.sec.gov, or by directing a request to: Avista Healthcare Public Acquisition Corp. II, 65 East 55th Street, 18th Floor, New York, NY 10022. Participants in the Solicitation APAC, Ligand and OmniAb and each of their respective directors, executive officers and other members of their management and employees may be deemed to be participants in the solicitation of proxies from APAC's shareholders in connection with the Business Combination. Shareholders are urged to carefully read the proxy statement/prospectus regarding the Business Combination when it becomes available, because it will contain important information. Information regarding the persons who may, under the rules of the SEC, be deemed participants in the solicitation of APAC's shareholders in connection with the Business Combination will be set forth in the registration statement when it is filed with the SEC. Information about APAC's executive officers and directors and OmniAb's management and directors also will be set forth in the registration statement relating to the Business Combination when it becomes available. No Solicitation or Offer This presentation and any oral statements made in connection with this presentation shall neither constitute an offer to sell nor the solicitation of an offer to buy any securities, or the solicitation of any proxy, vote, consent or approval in any jurisdiction in connection with the proposed Business Combination, nor shall there be any sale of securities in any jurisdiction in which the offer, solicitation or sale would be unlawful prior to any registration or qualification under the securities laws of any such jurisdictions. This communication is restricted by law; it is not intended for distribution to, or use by any person in, any jurisdiction where such distribution or use would be contrary to local law or regulation. Trademarks This presentation contains trademarks, service marks, and trade names of Ligand, OmniAb, APAC and other companies, which are the property of their respective owners. Solely for convenience, the trademarks, service marks, trade names and copyrights referred to in this presentation may appear without the TM, SM, Ⓡ or ⒸO symbols, but such references are not intended to indicate, in any way, that APAC, Ligand or OmniAb will not assert, to the fullest extent under applicable law, their rights or the right of the applicable licensor to these trademarks, service marks, trade names and copyrights. 3 OmniAb#4OMNIAB + AVISTA A COMBINATION OF TWO LEADING LIFE SCIENCES FRANCHISES OmniAb Track Record Platform People ●●● ● ● ● 55+ active global partners 250+ active discovery programs Two approved OmniAb-derived products, one BLA under FDA review with Breakthrough Therapy designation 23 clinical stage antibodies and 2 approved products BIOLOGICAL INTELLIGENCETM (BI) High-throughput screening technologies Industry's only four animal species platform (transgenic rat, mouse and chicken, and cow-derived) Scientific leadership in antibody discovery, genetic engineering, biology / ion channels and systems engineering 82 employees, including 74 in R&D Headquartered in Emeryville, CA AVISTA ● CAPITAL PARTNERS Successful track record of building sustainable growth healthcare companies over 25 years $8+ billion invested in 42 healthcare companies (1) Supported 80+ add-on acquisitions Public markets expertise: 15 IPOs in healthcare sector Significant domain knowledge with healthcare industry focus Creative and flexible investment approach $115 million of fully-committed equity financing provided to OmniAb 30 professionals, including leading healthcare industry experts Headquartered in New York, NY Source: Company materials and filings. (1) Total of $8 billion equity invested includes ~$3 billion from co-investors / co-sponsors. Total of 42 healthcare companies includes transactions at DLJMB, a predecessor firm to Avista. 4 OmniAb#5ADDING A LEADING DRUG DISCOVERY PLATFORM TO AVISTA'S PHARMA SERVICES PORTFOLIO I Discovery OmniAb AVISTA CAPITAL PARTNERS Built capabilities and competitive strengths to become partner of choice BI designed to yield industry's most diverse sets of high-quality antibodies Rapid deep sequencing of immune repertoires Differentiated ion channel capabilities Diversified business model Robust IP portfolio Early-Stage Research & Development BioReliance charles river eMolecules inc Research FOCUS MPIⓇ Diagnostics RESEARCH AVISTA CAPITAL PARTNERS Track record of creating value through: Investing to add new capabilities and accelerate revenue growth Late-Stage Development & Commercialization ( Margin expansion Accretive M&A to enhance scale and capabilities Creative financings Syneos Health Avista investment professionals have deep domain expertise in the pharma services sector Eight completed investments, including five successful exits via IPOs and sales to strategic acquirors Avista professionals' investment experience spans the full spectrum of drug development including drug discovery, preclinical / bio-analytical testing and late stage / post-approval SUBC 5 OmniAb#6TRANSACTION SUMMARY (1) (2) I ■ ■ Transaction Summary OmniAb, Inc., an antibody discovery business wholly owned by Ligand, has entered into a definitive agreement to merge with Avista Public Acquisition Corp. II (APAC) (NASDAQ: AHPA), valuing OmniAb at a fully diluted pre- money equity valuation of $850 million OmniAb to become an independent publicly traded company Anchored spin-off transaction is backed with committed capital from Avista and Ligand Tax-free distribution for existing Ligand shareholders via all SPAC consideration All-primary transaction will result in gross proceeds of up to $266 million, through a combination of: APAC's $236 million cash in trust Avista to invest $15 million at $10.00 per share and provide up to an additional $100 million to backstop redemptions $15 million contribution from Ligand Earn-out payable to existing Ligand shareholders of 7.5mm shares @ $12.50 and 7.5mm shares @$15.00 33% of Avista's sponsor shares (1.9 million) subject to earnout at the same thresholds as Ligand shareholders Closing Expected 2H 2022 ($m) Sources Note: APAC Cash Avista Minimum Commitment Ligand Contribution Total Illustrative Sources & Uses $236 15 15 $266 Uses Cash to Balance Sheet Estimated Transaction Fees Total $250 16 (1) $266 ($m, except per share amount) Pro Forma Enterprise Value Share Price Pro Forma Shares Outstanding Post-Transaction Equity Value (-Cash) Pro Forma Enterprise Value Assumes no redemptions. Excludes impact of 8.2 million Avista warrants and 7.7 million public warrants, each struck at $11.50. Excludes impact of 15.0 million Ligand earnout shares and 1.9 million Avista earnout shares. Up to 37.5% of Avista's earnout shares are immediately vested pro rata to any utilization of the $100 million backstop facility. Excludes OmniAb's expenses. Includes 1.5 million co-investment shares and 3.8 million sponsor shares. Ligand Shareholders Illustrative Pro Forma Ownership APAC Shareholders Avista Shares 20.3% 4.7%(²) 75.0% 6 $10.00 113.3 $1,133 (250) $884 OmniAb#7KEY MARKET COMPARABLES SUGGEST SUBSTANTIAL VALUE CREATION OPPORTUNITY Enterprise Value ($) in millions $1,961 ($835 Diversified Drug Discovery 252(1) Private Ligand OmniAb ADIMAB # of Active Programs 425 (2) $4,844 evotec 111 Source: Company materials, filings, and FactSet as of 03/18/22. (1) Includes 248 active programs with downstream economics. $2,216 AbCellera 78(3) (2) Includes total program initiations, Adimab does not disclose current active program count. (3) Includes 54 active programs with downstream economics. (4) Includes 3 programs from recent Merck collaboration. $567 absci. 12(4) Computationally-Enabled Drug Discovery $2,095 $1,878 $1,301 RELAY SCHRÖDINGER Exscientia HERAPEU ES Next-Generation Discovery and Production Technologies $3,726 GINKGO BIOWORKS $2,616 TWIST BIOSCIENCE $1,313 $1,203 CODEXIS Adaptive PROTEIN ENGINEERING EXPERTS 7 OmniAb#8EXPERIENCED LEADERSHIP TEAM WITH PROVEN TRACK RECORD OF SUCCESS OmniAb Leadership Team Matt Foehr Board Member CEO, OmniAb Inc. Board Member Viking Therapeutics Former Exec at Ligand, GlaxoSmithKline, Stiefel Labs, Connetics OmniAb Board Nominees John Higgins Board Chair CEO and Board Member, Ligand Former CFO, Connetics Corp Board Member Bio-Techne Kurt Gustafson CFO, OmniAb Inc. Board Member Xencor, Inc Former Exec at Spectrum Pharmaceuticals, Halozyme Theraputics, Amgen Carolyn Bertozzi, PhD Board Member Professor of Humanities & Sciences Stanford University Investigator HHMRI Former Board Member Lilly, Advisor to GlaxoSmithKline Founder of multiple companies Avista Leadership Team Thompson Dean Chairman and Co-Head of Investment Comittee, Avista Capital Partners Board member Cooper Consumer Health, eMolecules, National Spine & Pain Centers, Probo Medical, Vision Healthcare Sarah Boyce Board Member Chair of HC&C Committee CEO, Avidity Board Member Berkeley Lights Former Akcea Therapeutics, Ionis Pharmaceuticals, Forest Labs Jennifer Cochran, PhD Board Member Chair of Nominating Committee Professor of Bioengineering Stanford University Founder of multiple companies David Burgstahler Managing Partner and CEO, Avista Capital Partners Board member Cosette Pharmaceuticals, Inform Diagnostics, RVL Pharmaceuticals, United BioSource Corporation, XIFIN Sunil Patel Board Member Chair of Audit Committee Public & Private Biotech Executive Former Abgenix, Gilead, BiPar and OncoMed 8 OmniAb#9OmniAb THE OMNIAB PLATFORM#10SETTING THE STAGE - OMNIAB'S SPIN-OFF FROM LIGAND • Ligand's proven business model is focused on developing and acquiring technologies that enable the discovery and development of medicines ● 400+ fully-funded programs in various stages 1,600+ issued patents worldwide On November 9, 2021, Ligand announced its intention to split into two separate, publicly-traded companies - 140+ partners among pharmaceutical and biotechnology companies SpinCo: OmniAb, Icagen and other antibody discovery technologies - RemainCo: Core existing royalties and Captisol, Pelican technologies Anchored tax-free spin-off to create two well-capitalized companies Operational focus Business-specific capital allocation Agility to meet partner needs Opportunity to unlock value of OmniAb Ligand at a Glance Broad portfolio of 140+ different partners PELICAN P. Hluorescens expression technology CAPTISOL Discovery Preclinical Phase 1 Phase 2 Phase 3 Registration Approved Approved Registration Phase 3 Phase 2 Phase 1 Preclinical Discovery PROPRIETARY COMPOUNDS Note: Each dot in above graphic represents a program 10 OmniAb OmniAb#11ANTIBODIES AND INDUSTRY DEMAND HIGHER SUCCESS RATES FOR ANTIBODY MEDICINES DRIVE OUR INDUSTRY'S NEED FOR DISCOVERY TECHNOLOGY Existing Industry limitations Current approaches burdened with critical disadvantages - lack of antibody diversity, lengthy timelines, excess costs and lack of flexibility Increasing Antibody Market $236B in antibody sales by 2025 (up from >$184B in 2020) 41 blockbuster antibodies in 2020 (up from 36 in 2019) Five best-selling antibodies had ~$55B of sales in 2020 ● Higher Success Rates Type of Drug Small Molecules Biologics/Antibodies Clinical Success Rates (¹) 6.2% 11.5% Sources: 2020 Sales of Recombinant Therapeutic Antibodies, Proteins, Biosimilars & Other Biologics (La Merie Publishing). Clinical Development success rates 2006-2019 (Bio, Biomed tracker and Amplion). Historical success rates for antibody classes is nearly twice the rate of small molecules Tables of approved mAbs and antibodies in review available at https://www.antibodysociety.org/resources/approved-antibodies/ (1) Defined as composite success rate of clinical development from Phase I trials to regulatory submission. Acceleration of Regulatory Approvals (FDA and EMA) Substantial growth in number of new antibody therapeutics 70 60 50 40 30 20 10 Pre-2000 2011-2020 2001-2010 11 OmniAb#12OMNIAB HISTORY OVER 13 YEARS OF INVESTMENT BUILT OUR BEST-IN-CLASS PLATFORM 2008 OMT Founded 2016 Ligand Acquired OMT (OmniAb) Development of OmniRat/OmniFlic/OmniMouse & 16 partnerships signed ● 2017 • Crystal Bio (OmniChicken) 2018 2019 Ab Initio (Computationally Powered Antigen Design) Significant Internal Investment and R&D Next generation animals (Bispecifics, HCO, etc.) Expanded state-of-the art labs and added capacity Al-powered single-cell microcapillary platform Strategically built tech platform to optimally harness the power of BIOLOGICAL INTELLIGENCE™ 2020 Icagen (lon Channel Technology) xCella Taurus (OmniTaur) (Microcapillary Platform) 12 OmniAb#13OMNIAB'S HISTORICAL GROWTH WITHIN LIGAND PROGRESSION AND PERFORMANCE IN PROGRAMS BY STAGE OF DEVELOPMENT 2016 at Acquisition(¹) Preclinical: 1 21 (1) Estimated at the time of acquisition. Discovery: 20 Phase 2: 2 Phase 1: 18 Preclinical: 10. As of 12/31/21 Phase 3: 2 Registration: 1 252 -Approved: 2 Discovery: 217 Substantial progress in all phases, increase in discovery programs expected to rapidly feed growth in new clinical programs and future approvals 13 OmniAb#14THE OMNIAB PLATFORM Create Diverse Antibody Pools Create Diverse Pools of High-Quality Naturally Optimized Antibodies Screen Antibody Candidates Screen Millions of Cells to Find Potential Therapeutic Candidates Technology offering addresses critical industry needs and is paired with our highly specialized and efficient operation Identify the Right Antibody Further Characterize, Select & Optimize the Right Antibody We leverage our proprietary and differentiated technologies rather than commoditized industry services that are widely available from CROS or built into big pharma 14 OmniAb#15THE OMNIAB PLATFORM Create Diverse Antibody Pools OmniAb Technologies Create Diverse Pools of High-Quality Naturally Optimized Antibodies Computational Antigen Design & Proprietary Reagents mniRat OmniMouse OmniChicken Robust Antibodies for Any Target Omniflic OmniClic Bispecific Antibody Generation OmniTaur Cow-inspired Antibodies for Difficult Targets Screen Antibody Candidates Screen Millions of Cells to Find Potential Therapeutic Candidates xploration High-Throughput Single Cell Screening Gel Encapsulated Microenvironment (GEM) Single Cell Screening Identify the Right Antibody . Further Characterize, Select & Optimize the Right Antibody Custom Bioinformatics • Next Generation Sequencing (NGS) Hit Expansion . 088 88 IN Comprehensive Functional Characterization Proprietary lon Channel Assays Technology offering addresses the most critical challenges of antibody discovery 15 OmniAb#16THE OMNIAB PLATFORM Antibody Generation Technologies Computational Antigen Design & Proprietary Reagents mniRat mniMouse OmniChicken Robust Antibodies for Any Target OmniFlic OmniClic OmniTaur Cow-inspired Bispecific Antibody Antibodies for Difficult Targets Generation Create Diverse Antibody Pools Screen Antibody Candidates (1) In August 2021, zimberelimab, was approved in China for the treatment of recurrent or refractory classical Hodgkin's lymphoma, and in December 2021 sugemalimab, was approved in China for the first-line treatment of metastatic (stage IV) non-small cell lung cancer in combination with chemotherapy. Identify the Right Antibody We believe generating large and diverse pools of high-quality antibodies increases the likelihood of discovering the antibody with the most desirable therapeutic characteristics Industry's only four-species platform 23 in clinical development and two approved antibodies (1) A heritage of genetic engineering advancements Carefully designed transgenes for robust response Bispecific and cow-inspired technologies enable next generation therapeutics 16 OmniAb#17THE OMNIAB PLATFORM xploration Microcapillary Technology Image millions of cells Diverse and flexible assays Rapidly recover 1,000's of antibody sequences xploration 2.0 (in development) Ploration Create Diverse Antibody Pools Screen Antibody Candidates Identify the Right Antibody Gel Encapsulated Microenvironment (GEM) We offer two powerful single B-cell screening technologies: xploration and GEM assay Multi-parameter screening of tens of millions of cells in hours instead of weeks 17 Al selects and ranks thousands of promising therapeutic candidates from immense amounts of phenotypic data#18THE OMNIAB PLATFORM Our discovery teams are flexibly positioned to work closely with partners to identify the right antibody •Data from multi-parameter screening and performance assays used in combination with bioinformatics •High-throughput epitope binning and kinetics analysis, and target-specific functional assays Create Diverse Antibody Pools • Next generation sequencing (NGS) hit expansion to identify variant antibodies with improved characteristics • Proprietary assays for ion channel and transporter targets ● Screen Antibody Candidates Identify the Right Antibody 8 8 g g 18 OmniAb#19THE OMNIAB PLATFORM EXTENSIVE BIOLOGICAL CAPABILITIES ON ION CHANNELS AND TRANSPORTERS Proprietary cell lines enable high speed antigen production Create Diverse Antibody Pools Cutting-edge assays facilitate high-throughput screens in GEM and xploration platforms Screen Antibody Candidates Identify the Right Antibody Proprietary assays leveraged for discovery and characterization of ion channel antibodies Within OmniAb are differentiated capabilities for viable target-to-lead delivery for difficult and high-value ion channel targets 19 OmniAb#20OMNIAB BUSINESS MODEL OUR AGREEMENTS ARE STRUCTURED TO ALIGN ECONOMIC AND SCIENTIFIC INTERESTS WITH OUR PARTNERS License partnerships designed to include: Technology access and collaboration/service fees Milestones Royalties on commercial sales ● We have nearly $1.5 billion in contracted milestones from active OmniAb programs today (excluding antibody discovery programs), with continued growth expected as partners expand use of the platform and as we add new partners 20 OmniAb#21OMNIAB INTELLECTUAL PROPERTY ADVANTAGE PARTNERS FILING PATENTS ON OMNIAB-DERIVED ANTIBODIES CREATE DURABLE ROYALTY STREAMS AND A LENGTHY INTELLECTUAL PROPERTY TAIL ● We maintain a broad intellectual property estate with multiple long duration patent families covering each major element of our technology platform Licenses are structured so that royalties are linked to the patents for the antibodies discovered with OmniAb, thereby creating a lengthy coverage tail >60 patent filings by our partners claiming an OmniAb-derived antibody as primary invention, with expiries up to 2041 Over 300 patents issued worldwide Antibody Patent Applications filed by Partners 70 60 50 40 30 20 10 0 2014 2015 2016 2017 2018 2019 2020 2021 21 OmniAb#22SELECT OMNIAB PARTNERS >55 COMPANIES CURRENTLY HAVE ACCESS TO OMNIAB ANTIBODIES AMGEN Genmab MERCK Seagen® Aptevo™ Therapeutics GigaGen A Grifols Company ONO ONO PHARMACEUTICAL CO.,LTD. it's symphogen a Servier Company Boehringer Ingelheim BIOSCIENCES 誉衡生物 2Pfizer Takeda 1351 基石药业 CSTONE PHARMACEUTICALS Janssen sanofi Wuxi Biologics Global Solution Provider 22 OmniAb#23THE POWER OF OMNIAB PARTNER CASE STUDIES Partner A Emerging Biotech Novel multi-transmembrane target for triple negative breast cancer All previously-known antibodies to target could only bind to denatured or fixed form, therefore unsuitable for therapeutic use Our antigen tech was applied to deliver mg-scale quantities of purified receptor in native conformation for immunization and screening OmniChicken immunization led to discovery of a large and diverse panel of fully-human antibodies capable of binding target on live tissues Partner B Big Pharma • Growth factor target, highly conserved among mammals Human version of target non- immunogenic in other rodents; no titer achieved despite numerous immunization attempts by partner Genetic knockout of target gene attempted in mice but was lethal OmniChicken immunization led to robust titers and diverse antibody panels >90% of sequences recovered had excellent developability profiles based on multi-parameter in-silico analysis Partner C Established Biotech • Partner has history of success in developing antibodies, with large discovery group and expanding novel biology ● ● Partner needed a flexible, scalable antibody discovery solution to start dozens of new programs every year Deep collaboration to develop next generation rodents, which were tested in parallel with active novel programs OmniAb wholly owns rights to next- generation animals and can include them in the OmniAb technology offering to other partners Partner D Global Pharma ● Asia-based global pharma player that is establishing a new and substantial presence in antibody space with large investment and expansion of global antibody team Partner needed OmniAb's antibody discovery engine to power their growth Selected OmniAb as core technology to feed robust discovery and development efforts • Developed three-way collaboration with deep repertoire analysis to rapidly identify best binders for bispecific antibodies 23 OmniAb#24OMNIAB CLINICAL AND APPROVED PARTNER PIPELINE TWO APPROVED PRODUCTS AND 23 CLINICAL OMNIAB-DERIVED ANTIBODIES Partner gloria 誉衡生物 ARCUS 基石药业 BIOSCIENCES CSTONE PHARMACEUTICAS Janssen Johan Jokureu Genentech* A Member of the Bocke Group HANALL HARBOUR IMMUNOVANT Genmab Aptevo Janssen John Acken Janssen Janssen Johna Jakuen Merck Genmab symphogen symphogen symphogen! symphagen abbviet Ancora AMGEN + SalubrisBio O CURON Zhilkang Hongyi Boehringer Ingelheim Program Zimberelimab OmniRat Sugemalimab OmniRat OmniRat Teclistamab OmniRat OmniRat OmniRat OmniMouse OmniMouse OmniRat OmniRat OmniRat OmniRat OmniRat OmniRat OmniRat OmniRat OmniFlic OmniFlic OmniFlic OmniRat OmniRat OmniRat OmniChicken Tiragolumab Batoclimab GEN1046 APVO436 JNJ-67371244 JNJ-70218902 JNJ-78306358 M6223 GEN1047 SYM022 SYM023 SYM024 S095029 TNB-383B TNB-486 AMG 340 SAL003 CN1 Source Animal Undisclosed Undisclosed Area Oncology Oncology Oncology Oncology Immunology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Oncology Metabolic Oncology Oncology Undisclosed Target PD-1 PD-L1 BCMA x CD3 TIGIT FcRn PD-L1 x 4-1BB CD123 x CD3 CD33 x CD3 Undisclosed HLA-G x CD3 TIGIT B7H4 x CD3 LAG-3 TIM-3 CD73 NKG2A BCMA x CD3 CD19 x CD3 PSMA x CD3 PCSK9 Undisclosed 4-1BB Undisclosed Preclinical Animal launch year: OmniRat 2012; OmniMouse 2014; OmniFlic 2014; OmniChicken 2016; OmniClic 2019; OmniTaur 2020 Notes: Most advanced status for each program shown. Zimberelimab and Sugemalimab are approved in China. Phase 1 * Indicates programs with fully paid licenses. + Programs discovered by Teneobio under a fully paid licenses. Future programs discovered under license agreement are subject to downstream economics. Phase 2 Phase 3 Registration Approved 24 OmniAb#25COMPETITIVE BENCHMARKING THREE CLEAR LEADERS IN INTEGRATED ANTIBODY DISCOVERY Active Partners Active Programs Approved Registration Phase 3 Phase 2 Phase 1 Antigen Generation Species Diversity Screening Capabilities Identification Programs by Stage Technologies Capabilities OmniAb 56(1) 252(1) 2 1 2 NN 2 18 ✓✓✓ ✓✓✓ ✓✓✓ ✓✓✓ √✓ ✓ AbCellera 36(2,3) 78(2,3) 1 1 3 ✓ ✓✓✓ ✓✓✓ ✓✓✓ ✓ ✓ ADIMAB 95(3) 425(3) 1 55(3) x ✓ ✓ ✓ ✓ Analyze Engineer Sources: AbCellera Corporate Presentations dated 11/9/21 and 2/24/22; Adimab "Update on 2021 Partnership Activities" press release dated 1/12/22; Technologies capabilities based on Ligand's internal assessment. (1) Includes 56 active partners and 248 active programs with downstream economics. (2) Includes 26 active partners and 54 active programs with downstream economics. (3) AbCellera and Adimab do not disclose if programs or partnerships are ongoing or terminated. ✓✓ ✓✓✓ 25 OmniAb#26OMNIAB TEAM SCIENTIFIC LEADERSHIP Bill Harriman, PhD SVP, Antibody Discovery Co-Founder/CSO, Crystal Bioscience Trellis, Roche, Abgenix UCSF-Immunology, Haas MBA Shelley Izquierdo, PhD Sr. Director, Antibody Discovery Crystal Bioscience, Trellis UC Berkeley Marie-Cecile Van De Lavoir, PhD, DVM VP, Operations Co-Founder/COO, Crystal Bioscience Origen Therapeutics, Inventor Germ Cell Technology Fulbright Scholar, UCSF, Utrecht, Guelph, Cornell Phil Leighton, PhD Sr. Director, Molecular Biology Genetic Engineering Lead, Crystal Bioscience and Origen Princeton, UCSF Christel Iffland, PhD VP, Antibody Technology Former Associate Director at Merck KGaA / EMD Serono, Co-inventor of Avelumab Dana Farber, Albert Einstein College Bob Chen, PhD Sr. Director, Systems Engineering Former Exec at xCella Bio (Co-Founder/CTO) Stanford Bioengineering 26 Doug Krafte, PhD SVP, Ion Channels Former Exec at Icagen, Pfizer Pain & Sensory Disorders, Boehringer Ingelheim, Aurora Biosciences Univ. Rochester, Vanderbilt Ellen Collarini, PhD Sr. Director, Cell Biology Crystal Bioscience, Trellis, Roche Univ. Michigan, Univ. College-London OmniAb#27OmniAb FINANCIAL REVIEW#28ADVANCED PIPELINE DRIVING DIVERSIFIED REVENUE KEY INFORMATION ● ● ● Expanded to >55 active partners with whom we have active license agreements or who have an active program Significant active program growth since acquisition Royalty revenue expected to grow significantly with average royalty rates typically in the low- to mid-single digits Iterative improvements of antibody discovery engine expected to continue driving royalty rates and market share higher Long-term value of our business will be driven by downstream royalty payments 28 OmniAb#29OMNIAB KEY PERFORMANCE INDICATORS HIGHLY SCALABLE BUSINESS MODEL ● Strong consistent growth in key performance indicators ● Active Partners(1): >30% CAGR since 2014 Active Programs(²): >25% CAGR since 2016 Highly scalable, with a large number of programs performed entirely by partners 60 50 40 30 20 10 0 Number of Active Partners 2014 2015 2016 2017 2018 2019 2020 2021 300 250 200 150 100 50 Number of Active Programs 17 ** 2014 (1) Represents the unique number of partners with whom we have active license agreements or who have an active program. (2) Represents programs for which an antigen is introduced into our animals and remains so as long as the program is actively being developed or commercialized. Active Programs not tracked prior to acquisition of Open Monoclonal Technology, Inc. in January 2016. * 2015 2016 2017 2018 2019 2020 2021 Number of Active Clinical and Commercial Programs 25 20 15 10 5 0 2014 2015 2016 2017 2018 2019 2020 2021 29 OmniAb#30UNIT ECONOMICS AND PIPELINE DEVELOPMENT TO DRIVE FUTURE VALUE Key Value Drivers Per program economics Research fees Clinical and commercial milestones Royalties ■ Current Portfolio NPV per program Peak sales ■ Average royalty rates Probability of success Time to approval Time to peak sales (1) 2020 Sales of Recombinant Therapeutic Antibodies, Proteins, Biosimilars & Other Biologics (La Merie Publishing). + Expected market growth Pipeline Development Portfolio expansion Investments in go-to-market initiatives Risk-sharing with partners ■ $236B in antibody sales by 2025(1) Up from $184B in 2020(1) Ab market opportunity Antigen generation Screening technologies ☐ Next-generation identification and optimization 30 OmniAb#31ILLUSTRATIVE REVENUE PROFILES FOR SUCCESSFUL PARTNERED PROGRAMS OMNIAB PARTICIPATION IS WEIGHTED TOWARDS DOWNSTREAM SUCCESS Flexible transaction structures enable optionality for partners while maintaining value for OmniAb Program A Program B Research / Upfront Clinical Milestones Commercial Milestones / Royalties Target equivalent NPV for all structures 31 1 Per product gross revenue potential, if approved and marketed, of up to $1 billion+ to OmniAb OmniAb#32OmniAb APPENDIX#33ZIMBERELIMAB APPROVED THE FIRST APPROVED OMNIRAT-DERIVED ANTIBODY ● gloria • On August 30, 2021, zimberelimab (GLS-010), an OmniAb-derived fully human anti-PD-1 mAb, was approved in China for the treatment of recurrent or refractory classical Hodgkin's lymphoma Marks the first approval of an OmniAb-derived mAb - BIOSCIENCES In 2015, GloriaBio contracted with WuXi Biologics to discover and develop zimberelimab in China using OmniRat Zimberelimab entered clinic in March 2017, and NDA was submitted to China NMPA in February 2020 GloriaBio is also investigating zimberelimab in advanced solid tumors, and was granted Breakthrough Therapy designation for the treatment of patients with recurrent/metastatic cervical cancer in March 2021 Zimberelimab is being developed by Arcus Biosciences (in collaboration with Gilead) in North America, Europe, Japan and certain other territories through a 2017 agreement 33 OmniAb#34SUGEMALIMAB APPROVED THE SECOND APPROVED OMNIRAT-DERIVED ANTIBODY ● 1361 基石药业 CSTONE PHARMACEUTICALS 34 On December 21, 2021, CStone announced approval in China for Cejemly® (sugemalimab) Fully-human, full length anti-PD-L1 monoclonal, said to mirror the natural G-type immunoglobulin 4 (IgG4), which reduces immunogenicity risks and potential toxicity, approved as part of first-line treatment for metastatic nonsquamous NSCLC Touted by CStone as "first and only anti-PD-L1 approved for first-line treatment in metastatic nonsquamous NSCLC anywhere in the world" CStone also has an NDA pending for Cejemly® for Stage III NSCLC Pfizer responsible for commercializing in China via 2020 strategic collaboration EQRx licensed exclusive rights to sugemalimab for development / commercialization outside of China, targeting filings by year-end OmniAb#35OmniAb For more information, please visit www.omniab.com