Chimerix Investor Conference Presentation Deck

Response Assessment Criteria for Glioma ● RANO LGG response defined by decrease in T2 FLAIR RANO- LGG Criterion T2/FLAIR New lesion Corticosteroids Clinical status CR Disappearance of all lesions None (apart from those consistent with radiation effects, and no new or increased enhancement) None Stable or t Requirement for response All PR >50% in perpe dicular diameters of lesion, sustained for 4 weeks None (apart from those consistent with radiation effects, and no new or increased enhancement) Stable or ↓ Stable or t All T2- FLAIR MR 25-50% ↓ in perpendicular diameters of lesion None (apart from those consistent with radiation effects, and no new or increased enhancement) Stable or ↓ Stable or t All SD <25% to 25% T1-Gd+ None (apart from those consistent with radiation effects, and no new or increased enhancement) Stable or ↓ Stable or t All PD ≥25% t Present Zoom F NA ‡ ↓t (not attributable to other causes apart from the tumor, or decrease in corticosteroid dose) Any‡

View entire presentation