OmniAb Investor Conference Presentation Deck
Common Light Chain Platforms for Bispecific Antibodies
STANDARD IgG FORMAT TO DE-RISK DOWNSTREAM DEVELOPMENT+
OmniFlic
Rearranged
IgVK3-15/JK1
JK2-5
0000-
IgKC
Rearranged human VK3-15 light chain
combined with diversifying heavy chain
+The Evolution of Bispecifc Antibodies, Nimish Gera
https://doi.org/10.1080/14712598.2022.2040987
Bispecifics are a growing area of therapeutics (20% of mAbs in clinic)
~30% of new OmniAb programs seek to use OmniFlic or OmniClic
OmniClic
Simple reformatting from
monospecific into bispecific
for efficient production
Bispecific IgG
IgVK3-15/JK1
"Germlining" human VK3-15 light chain
combined with diversifying heavy chain
Monospecific IgG
13
Common light chain for
OmniFlic and OmniClic
allows interchangeability
between the platforms
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