Chimerix Investor Conference Presentation Deck

Waterfall Plot (RANO-HGG) 14 Best % Change in SPD from Baseline * 100 75 50 25 -25 -50 -75 -100 * ||100. -000 ooo Change > 100%, CR=complete response, PR-partial response, SD=stable disease, NE=not evaluable, PD=progressive disease SPD=sum of products of perpendicular diameters (target enhancing lesions per BICR) Only patients with measurable target enhancing lesions by BICR at baseline and with post-baseline evaluations are included. PD NE SD PR CR Three patients did not have on-treatment monotherapy MRIs available for BICR; one patient censored prior to first on-treatment MRI; one patient did not have measurable target lesion.

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