Chimerix Investor Conference Presentation Deck

Waterfall Plot (RANO-LGG) 17 Best % Change in SPD from Baseline * 100 75 50 25 0 -25 -50 -75 -100 000... U PD NE SDMR □ PR Change > 100%, PR-partial response, MR-minor response, SD=stable disease, NE=not evaluable, PD=progressive disease SPD=sum of products of perpendicular diameters (target non-enhancing lesions per BICR) Only patients with measurable target lesions by BICR at baseline and with post-baseline evaluations are included. Three patients did not have on-treatment monotherapy MRIs available for BICR; one patient censored prior to first on-treatment MRI. 00

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