Chimerix Investor Conference Presentation Deck

ONC201 Is a DRD2 Antagonist/ClpP Agonist 5 ClpP 12A ONC201 Mitochondria 17A Cytoplasm OXPHOS proteins Integrated stress response CHOP ATF4 DRD2 ERK AKT Cell death pathways Cell survival signals Dead cancer cell Selective killing of cancer cells Allen et al., Science Translational Medicine, 2013 Ishizawa et al, Science Signaling, 2016 Kline et al, Science Signaling, 2016 Siegelin et al, Clinical Cancer Research, 2018 Ishizawa et al, Cancer Cell, 2019 ONC201 Extracellular space Ras signaling pathways ● ● ● Oral small molecule Once weekly dosing based on pharmacodynamics Well tolerated DRD2 antagonist and ClpP agonist that induces tumor cell apoptosis

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