Chimerix Investor Conference Presentation Deck

8 Waterfall Plot (RANO- HGG) Stratified by Age Responses observed across age groups: <18 years: 1/4 (25%) 18-40 years: 5/32 (16%) >40 years: 4/14 (29%) RANO-HGG response of 8-year- old subject confirms activity in this population - 27 Best % Change in SPD from Baseline 100 75 50- 25 O -25 -50 -75 -100 * Change > 100%, SPD-sum of products of perpendicular diameters (target enhancing lesions per BICR) Only patients with measurable target enhancing lesions at both baseline and post-baseline are included. 18-<40 ☐ <18 240 O 2021 Chimerix, Inc

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