Chimerix Investor Conference Presentation Deck

Overall Response Rate (RANO-HGG) 13 RANO-HGG¹ ORR (CR + PR) Complete Response (CR) Partial Response (PR) Stable Disease (SD) Not Evaluable (NE)² Progressive Disease (PD) Not Applicable (NA)³ Disease Control Rate (CR + PR + SD) N=50 10 (20%) 95% CI: 10 - 34% 1 (2%) 9 (18%) 10 (20%) 8 (16%) 18 (36%) 4 (8%) 20 (40%) 95% CI: 26 – 55% ¹Integrated RANO HGG criteria assessment by dual reader BICR 2Five overall radiographic SD accompanied by increase in corticosteroids; 3 overall radiographic PD accompanied by decrease in corticosteroids ³Three patients did not have on-treatment monotherapy MRIs available for BICR; one patient censored prior to first on-treatment MRI

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