Chimerix Investor Conference Presentation Deck

✓ Waterfall Plot (RANO- HGG) Stratified by Performance Status ● ● 26 Expectedly, patients with higher PS were more likely to respond to treatment 100: 1/2 (50%) 90: 4/14 (29%) 80: 4/20 (20%) - 70: 1/7 (14%) 60: 0/7 (0%) - Consistent with hypothesis that treating earlier in disease course may enhance efficacy Best % Change in SPD from Baseline 100 75 50 25 O -25 -50 -75 -100 T 1110 * Change > 100%, SPD-sum of products of perpendicular diameters (target enhancing lesions per BICR) Only patients with measurable target enhancing lesions at both baseline and post-baseline are included. 060 ☐ 070 080 090 ☐ 100 © 2021 Chimerix, Inc

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