Chimerix Investor Conference Presentation Deck

Diffuse Midline Glioma, H3 K27M-mutant Me he G34VIR Thalamus 4 G34V/R Pons Medulla oblongata G34V/R K27M K27M G34V/R Lulla et al., Science Advances, 2016 Fa G34V/R ● ● ● H3 K27M is detected in 50-90% of midline gliomas More prevalent in pediatric populations but also prevalent adults as well Highly aggressive malignancy; invariably lethal No effective drug therapies to date for recurrence No definite objective responses to systemic therapies by RANO HGG reported in literature in the recurrent setting Other midline sites- Thalamus. Pons Spinal cord. ● : 0 10 20 30 40 50 60 Patient age (years) Solomon et al., Brain Pathology 26 (2016) 569–580

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