#1Advancing Animal Health Zoetis Investor Overview zoetis#2Zoetis at a Glance 70+ Years of experience 100+ Countries with market presence 2 $8.1B Annual revenue 8 Core animal species 7 Major product categories 64% 1 Revenue from companion animal products 29 Manufacturing sites 1 35% Revenue from livestock products Note: Facts and figures shown are as of Dec. 31, 2022 ¹Excludes revenue associated with Client Supply Services and Human Health, which represented 1% of total 2022 revenue. 1,430 Approximate R&D colleagues 13,800 Approximate colleagues worldwide 4,200 Approximate field force members MAPOD We provide: Medicines Vaccines Diagnostics Genetic tests Biodevices Precision animal health zoetis#3Our Executive Team 3 Kristin Peck Chief Executive Officer Nick Ashton Executive Vice President and President, Global Manufacturing and Supply Wetteny Joseph Executive Vice President and Chief Financial Officer Jamie Brannan Executive Vice President and President, International Operations and Aquaculture Heidi Chen Executive Vice President, General Counsel & Corporate Secretary; Business Lead of Human Health Diagnostics Roxanne Lagano Wafaa Mamilli Executive Vice President, Chief Executive Vice President, Human Resources Officer and Chief Digital and Technology Global Operations Officer and Group President, China, Brazil and Precision Animal Health Rimma Driscoll Executive Vice President, Head of Global Strategy, Commercial and Business Development, and Global BioDevices Rob Polzer Executive Vice President and President, Research and Development Jeannette Ferran Astorga Executive Vice President, Corporate Affairs, Communications and Chief Sustainability Officer zoetis#4Purpose is a Core Part of Our Story Why: Our Purpose How: Our Strategy To nurture our world and humankind by advancing care for animals Reimagining animal health Drive innovative growth Enhance customer experience Lead in digital and data analytics Cultivate a high-performing organization Champion a healthier, more sustainable future Our Core Beliefs Form the Foundation of Our Culture. Our colleagues make the difference Always do the right thing Customer obsessed Run it like you own it What: Our Products and Services Continuum of Care predict ∞ Treat Detect We are one Zoetis Prevent Medicines, Vaccines, Diagnostics and Technologies zoetis#5Diverse, Durable and Innovative Portfolio Diversity across geographies, species and therapeutic areas drives steady performance 5 7 therapeutic areas 15¹ blockbusters ~300 product lines 8 core species -30² year average market life of key brands in portfolio >2,000 new products and lifecycle innovations introduced in last 10 years 1 Estimated number of blockbuster products with revenues of $100M or more as of year-end 2022 2 Market life refers to the number of years a product has been commercially available. zoetis#6World Leader in Animal Health¹ By Species Market Leader in Species Representing ~90% of Our Portfolio by Revenue ³ Companion Animal #1 Cattle Fish ³ Swine Poultry #1 #1 #1 #5 By Product Category Other Pharma² Anti-Infectives Medicated Feed Additives (MFA) Vaccines (Biologicals) Diagnostics 3 Parasiticides 1 Vetnosis Year-to-Date Q3 2022 Update. Rankings are based on revenues. 2 Includes pain, sedation, internal medicine, dermatology, etc. 3 Zoetis internal estimates 6 #1 #1 #2 #2 #3 #3 By Geography North America Latin America Asia Eastern Europe Western Europe #1 #1 #1 #2 #2 High Growth Franchise Areas ³ Dermatology Pet Pain Pet Parasiticides #1 #1 #2 zoetis#7Our Five Strategic Priorities Accelerating our strategy for growth 7 Drive Innovative Growth Enhance Customer Experience Lead in Digital and Data Analytics Champion Cultivate a High-Performing a Healthier, More Organization Sustainable Future zoetis#8Five Key Growth Drivers in 2023 8 ez Companion animal parasiticides Osteoarthritis (OA) pain Key dermatology portfolio Global diagnostics Growth in emerging markets. zoetis#99 86% of pet owners would pay whatever it takes if their pet needed extensive veterinary care.1 KEY TRENDS IN PETCARE The Human-Animal Bond Pet owners are prioritizing health and wellness of their animals Gen-Z and Millennials are fueling the humanization of pets High income households often have more than one pet and are more willing to spend during a down economy When faced with a 20% decrease in budget, pet owners will not spend less on their pets.² ¹ International Survey of Pet Owners and Veterinarians from HABRI/Zoetis. Published January 2022. 2 Zoetis Market Research, Dec. 2022 zoetis