#1ES EXACT SCIENCES First quarter 2021 X ADVANCING THE LEADING CANCER DIAGNOSTICS COMPANY EXACT SCIENCES x X X XX XX XX XXX XXX XX XXX XXX XXXX XX XXXX XXXXXXXXXXX XXXXXXXXXXXX XXXXXXXXXXXX XXXXXXXXXX XXXXXXXXXXXX XXXXXXXXXXX XXXXXXXXXXXX#2#3#4Exact Sciences is a leading, global, advanced cancer diagnostics company Our people 5,000 employees 1,000+ person commercial team 400 skilled R&D employees Our tests 4M+ people tested in 2020 cologuard Rx only oncotype DX oncotype MAP™ Why Exact will lead diagnostics Broad and advanced capabilities, relationships, and foundation Attacking cancer through early detection beginning with screening Supporting largest markets across the continuum totaling >$60B t#5#6#7#8#9#10#11#12#13#14#15#16#17#18#19#20#21#22#23#24#25#26#27#28#29#30#31#32#33