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ANNUAL REPORT 2021

LUNDBECK ANNUAL REPORT 2021 = CONTENTS IQVIA 19/111 INTERNATIONAL MARKETS Revenue from International Markets, which comprises all Lundbeck's markets outside of Europe and North America, reached DKK 4,155 million in 2021. The growth of 6% in local currencies was driven by RexultiⓇ/RxultiⓇ and BrintellixⓇ/TrintellixⓇ. The biggest markets are China, Japan, South Korea, Australia and Brazil. China and Japan constitute approximately 40% of the regional revenue. The strategic brands increased by 27% in local currencies and reached DKK 1,067 million or 26% of sales. In local currencies, all products grew compared to last year. Other pharmaceuticals declined by 5%. International Markets constituted 26% of total revenue (excluding effects from hedging and Other revenue), which is a small decrease from last year. Abilify MaintenaⓇ reached DKK 226 million in revenue representing a growth of 8% (4% in local currencies). Sales mainly derived from Australia where Abilify MaintenaⓇ shows robust sales performance. BrintellixⓇ/TrintellixⓇ reached DKK 739 million in revenue or an increase of 32% in local currencies. BrintellixⓇ/TrintellixⓇ realized solid growth across several markets including China and Japan. China, Brazil, Japan, South Korea and Mexico are the largest markets for BrintellixⓇ/TrintellixⓇ in the region. In China, BrintellixⓇ has a value share of 1.4% by October 2021*. In Japan, TrintellixⓇ is showing very strong momentum and has reached a volume market share of 5.5% by December 2021*. RexultiⓇ/RxultiⓇ reached DKK 99 million in sales and grew by 55% in local currencies. In International Markets, the product has its highest sales in Australia followed by Brazil. VyeptiⓇ received approval in the U.A.E. in December 2020 and in Kuwait in May 2021. In June 2021, The Australian Therapeutic Goods Administration (TGA) approved VyeptiⓇ for the preventive treatment of migraine in adults with a very strong label. VyeptiⓇ was introduced in the U.A.E. towards the end of September 2021. CipralexⓇ/LexaproⓇ generated revenue of DKK 1,699 million representing a growth of 4% in local currencies. Japan, China, South Korea, Brazil and Hong Kong are the largest markets for CipralexⓇ/LexaproⓇ in the region. Other pharmaceuticals generated revenue of DKK 1,389 million. AzilectⓇ is promoted by Lundbeck in some countries in Asia. AzilectⓇ generated revenue of DKK 135 million following a growth of 13%. EbixaⓇ generated revenue of DKK 397 million, which is 20% lower compared to 2020 following the inclusion of EbixaⓇ into Volume-Based Procurement (VBP) in China in the fourth quarter of 2020. REVENUE - INTERNATIONAL MARKETS DKKm Abilify MaintenaⓇ BrintellixⓇ/TrintellixⓇ RexultiⓇ/RxultiⓇ Strategic brands CipralexⓇ/LexaproⓇ Other pharmaceuticals Total revenue Growth 2021 2020 Growth in local currencies 226 210 8% 4% 739 583 27% 32% 99 65 52% 55% 1,067 858 24% 27% 1,699 1,730 (2%) 1,389 1,469 (5%) 4,155 4,057 2% 4% (4%) 6%
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