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Investor Presentaiton

Globalization Has Entered into Substantial Development Stage Southeast Asia (Marketed) HLX10-Serplulimab Serplulimab has been approved for 1L ES-SCLC by Indonesia's food and drug administration (BPOM), becoming the first marketed China-made PD-1 mAb in Southeast Asia (Marketed) HLX02-Trastuzumab biosimilar • HANQUYOU has marketed in 40+ countries and regions, including the EU, Australia, Argentina, Saudi Arabia, Singapore etc., and is expected to be approved in the US in 2024. The 2023 ex-China sales of HANQUYOU (revenue reported by Henlius) has reached RMB 93M Serplulimab MAA under EMA review Europe PD-(L)1 market in Europe Expected to exceed US$28B1 in 2030 USA Japan Serplulimab bridging study in the US is in progress PD-(L)1 market in the US Expected to reach US$48.4B1 in 2030 Explore potential market with unmet medical needs PD-(L)1 market in Japan Expected to exceed US$8.4B1 in 2030 . • HLX11-Pertuzumab biosimilar MRCT has enrolled 908 patients globally, expected to be the first approved Pertuzumab biosimilar in the US and Europe As the 2023 sales of the originator drug was over US$3.95B2, HLX11 will have a promising global market prospect by licensing collaboration with ORGANON HLX14- Denosumab biosimilar MRCT has enrolled 514 patients globally, and HLX14 is expected to file BLA in the US in 2024 As the originator drug achieved over US$6.16B2 sales in 2023, HLX14 will have a promising global market prospect by licensing collaboration with ORGANON 8 1.Data source: IQVIA MIDAS AUDITED VALUE, the European market includes EU and the UK 2. From the annual report of the originator drug owners O 2024 Henlius. 2 Henlius
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