Kymera Investor Day Presentation Deck

IRAK4 protein levels overexpressed in HS patient skin lesions IRAK4+ Cells per mm² 9000 6000 3000 Protein Expression 0 0.4 0.3 0.2 0.1 0.0 Immunofluorescence (IF) Lesion 3 IRAK4 Protein Expression in Autoimmune Diseases Upregulation in Skin of HS Patients Compared to Healthy Subjects 0.0084 Lesion 0.00016 2.6e-05 1.6e-07 Mass Spectrometry (MS) Peri-lesion Non-lesion Healthy 3.9e-06 8 0.0003 1.2e-05 0.34 t Peri-lesion Non-lesion Healthy KYMERA ©2021 KYMERA THERAPEUTICS, INC. Histology H&E IF Stain Nuclear IRAK4 Morphology Mask Epidermal Keratinocytes Dermal Immune cells IRAK4 expression is upregulated in dermis and epidermis of HS patients relative to healthy subject skin Lesion Peri-lesion Non-lesion Healthy subject KYMERA R&D DAY - December 16th, 2021 IRAK4+ Cells per mm² IRAK4+ Cells per mm² 6000- 4000- 2000- 9000 6000 3000 0 Dermal Immune Cells Lesion % 0.35 Lesion 0.00046 Epidermal Keratinocytes 0.47 Peri-lesion Non-lesion Healthy 4e-05 0.43 .8 0.011 0.0033 0.0021 Peri-lesion Non-lesion Healthy Alavi et al., Society for Investigative Dermatology Annual Meeting, 2021 PAGE 22

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