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Investor Presentaiton

Pfizer Offers Robust Differentiated Pipeline of Immuno-Inflammation Potential Therapies 3C D Rheumatology Rheumatoid Arthritis; Lupus; Dermatomyositis; Psoriatic Arthritis and Ankylosing Spondylitis Gastroenterology Currently Marketed Products Inflectra™ infliximab XELJANZ [tofacitinib] Enbrel etanercept Ixifi infliximab Investigational Assets ADALIMUMAB-AFZB Adalimumab biosimilar a-IFNẞ IRAK4/Ritlecitinib Combo Covalent JAK3/TEC Inflectra™ infliximab TL1A [tofacitinib) RITLECITINIB Ixifi infliximab Covalent JAK3/TEC Inflammatory Bowel Disease (Crohn's Disease & Ulcerative Colitis); Liver Fibrosis XELJANZ Medical Dermatology Atopic Dermatitis; Acne; Psoriasis; Alopecia Areata; Vitiligo; Pfizer Hidradenitis Suppurativa • • eucrisa crisaborole ointment 2% Enbrel etanercept Not all products are approved in all jurisdictions. Pfizer has rights to Enbrel outside the US and Canada CIBINQO (abrocitinib) tablets) 50ma 100ma 200m Etrasimod* S1P RITLECITINIB Covalent JAK3/TEC Etrasimod* S1P PDE4+ * If acquired 12
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