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Investor Presentation

40 Investor presentation First six months of 2022 The total branded diabetes market has a global value of DKK -310 billion annually DKK Global diabetes market billion DKK billion The USA +7% 400 150 143 139 2021 2020 Growth at CER +10% -10% +24% 100 313 69 58 -9% 293 300 50 41 48 +14% 14 17 19 17 200 100 0 Total -2% 112 117 Insulin 0 Total Insulin GLP-1 DPP-4i SGLT-2i Outside the USA DKK billion +28% +11% 170 154 150 97 +3% -3% 78 +26% -1% 100 55 58 71 70 +36% +36% 49 40 40 41 50 29 21 30 23 0 GLP-1 DPP-4i SGLT-2i Total Insulin GLP-1 DPP-4i SGLT-2i Source: Company announcements as of Q4 2021 Note: The segment value is based on reported figures, whilst the market growth is under constant exchange rate (CER). For Novo Nordisk the diabetes growth includes Insulin and GLP-1, excluding 'other Diabetes care'. Novo NordiskⓇ
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