Investor Presentaiton
Innovation: gepotidacin - a potential novel antibiotic to treat uUTI¹
Outpatient antibiotic resistance rates highlight need for new antibiotics
Annual incidence
in women c.12%
15m episodes
annually in US
c.30% of
UUTI patients
experience 1 or
more failures
40% of women feel
symptoms restrict
daily activities
Large
addressable
patient
Burden of
disease
population
C
High
Treatment
antibiotic
failure
resistance
rates
>20% resistance
to FQ2 and SXT3
agents
Diminishing utility of existing antibiotic classes
for uUTI6
30%
25%
25%
20%
20%
15%
10%
5%
0%
7%
3%
Proportion of E. coli Isolates (%)
| SXT NS (n=67,189)
ESBL+ (n=19,576)
FQ NS (n=54,359)
NFTONS (N=9,453)
1. Uncomplicated urinary tract infection 2. Fluoroquinolone 3. Trimethoprim sulfamethoxazole
4. Extended spectrum beta lactamases 5. Nitrofurantoin 6. Kaye KS, Gupta V, Mulgirigama A, Joshi A, Scangarella-Oman N, Yu K, Ye G, and
Mitrani-Gold FS. Trends in Antimicrobial Resistance Among Outpatient Urine E. coli Isolates in US Females ≥12 Years of Age: A Multicenter Evaluation From 2011 to 2019. Oral and Abstract/Poster presentation 1698, ID week, Oct. 21-25 2020.
GSK
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