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Investor Presentaiton

Financial Results for Q4 FY2022 Marketing Status of MYFEMBREEⓇ Approx. 19,700 total prescriptions (TRX) in Q4 FY2022 (29% growth vs. Q3 FY2022) +29% 19,783 15,380 10,406 7,664 4,924 2,572 469 Q2 FY2021 Q3 Q4 Q1 Q2 Q3 Q4 FY2021 FY2021 FY2022 FY2022 FY2022 FY2022 Number of prescriptions per quarter with MYFEMBREE®* The market targeted by MYFEMBREEⓇ is approx. 63 billion yen/year (gross conversion), and recently expanded by approx. 20% annually** Also focus on switching from oral contraceptives, NSAIDs, and surgery to MYFEMBREEⓇ Established broad health plan coverage (Percentage of total commercial lives as primary coverage obtained as of March 2023; for UF was >90% and endo. was >80%) ■Gathering new evidence for further potential utility (To leverage data of long-term administration for endo. and verify contraceptive efficacy) ■ Continue to improve Gross to Net *Source Symphony Health, an ICON plc Company, IDVⓇ **Source IQVIA NSP sales as of end of Feb. 2023 and TRX as of end of Mar. 2023. Sales for MYFEMBREE®, ORIAHNN, ORILISSA, Lupron Depot 3.75MG/11.25MG, and Lupaneta Pack for the 12 months ended Feb. 2023 were $481M (130yen/$), which reflects a 19% growth vs 12 months ended Feb. 2022
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