Investor Presentation - First Six Months of 2021

43 Investor presentation First six months of 2021 Insulin market size and volume share of growth and market share Insulin market share and market size (DKK billion) Total 44% Long- Acting 37% Fast- 52% 88 87 Acting 67% Premix 17 35% Human 23 129 Novo Nordisk Competitors Market growth A Market share 257 -5.5% -0.7% 80% Insulin volume: Share of growth and market share Novo NordiskⓇ 15% 13% 60% -3.6% -0.9% 11% 47% 9% 40% 7% -7.3% -0.1% 5% 20% 2% 3% 1% -9.1% +1.3% 2% 0% -1% May May 2018 2021 -NN market share -6.2% -0.8% Source: IQVIA, May 2021, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Market growth (right axis) NN growth (right axis)

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