Roche Pharmaceutical Development and Sales Overview

Expected currency impact 2022 CHF / USD Average YTD 2022 +2% +4% +4% +5% 0.94 0.95 0.96 0.92 0.90 Average YTD 2021 0.91 0.91 0.91 Roche Assuming the 30 September 2022 exchange rates remain stable until end of 2022, 2022 impact¹ is expected to be (%p): 0.92 0.92 0.93 0.94 0.98 0.97 0.97 0.96 0.97 0.98 0.98 0.98 T Monthly avg fx rates 2022 Fx rates 30th September Q1 HY Sep FY YTD Sales -1 0 -1 -1 CHF / EUR Core -5% -6% -7% -8% operating profit 0 -2 1.09 1.09 1.09 1.08 Core EPS 0 -2 1.04 1.03 1.01 1.00 1.04 1.05 1.02 1.02 1.04 1.03 0.99 0.97 0.96 0.96 0.96 0.96 Monthly avg fx rates 2022 Fx rates 30th September 1 On group growth rates 48 48

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