Investor Presentation H1 2023

54 Investor presentation First six months of 2023 Insulin market size and volume share of growth and market share Insulin market share and market size (DKK billion) Total 44% Long- Acting 38% Fast- 52% Acting 70% Premix 15 31% Human 23 96 96 136 Novo Nordisk Competitors Market growth A Market share 270 0.6% +0.1% 50% 40% -0.0% +0.9% 30% 4.8% -0.3% 20% Insulin volume: Market share 10% -12.7% +1.1% 0% May -1.9% -2.2% 2020 -NN market share Source: IQVIA, May 2023, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Novo NordiskⓇ 46% 10% 7% 4% 1% -2% -2% -5% -5% May 2023 Market growth (right axis) NN growth (right axis)

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