Pharma Update

Why we changed our customer engagement model Why we changed Roche's changing portfolio Shifting customer expectations for industry engagement Data and technology as disrupters Price pressures Roche In-person, product-specific field approach not meeting customer needs Industry representative's access to physicians (US) 100% 80% 77% 60% 65% 40% 44% 20% 15-30% 0% 2008 2012 2016 2020 (COVID) Patient influence in healthcare decision making • Providers increasingly refused to meet industry; customers confused by multiple touchpoints • Desire for more scientific exchange and patient/ account support 40 40

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