Orthofix Investor Presentation Deck

● ● ● Orthofix Growth Drivers: Future Notable growth opportunities through new indications and procedural solutions LONG TERM ASC SOLUTIONS Neo Medical partnership single use sterile instruments Cervical platform Patient-centric solutions $800 million market opportunity MID-TERM PEDIATRICS TrueLokTM expansion through radiolucent rings and struts Comprehensive pediatric plating system $800 million market opportunity ● ● FITBONE Trochanteric nail system for U.S. pediatric use Bone transport for trauma Expanded size offering $600 million market opportunity ● ● ● RCSTIM Rotator Cuff IDE clinical trial under way Entry into soft tissue repair First of its kind therapy Large un-served market ● CGBIO Conduct IDE clinical trials for U.S. FDA premarket approval Commercialize Novosis™ rhBMP-2 growth factor in the U.S. and Canada $650 million market opportunity NOVOSIS™ Recombinant una Morphoge P rhBMP-2 ● ● ● FITSPINE Early intervention growth rod Pediatric / adolescent scoliosis Limited competition Further differentiates pediatric portfolio $400 million market opportunity ORTHOFIX 15

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