BioNTech Investor Day Presentation Deck

Understanding and exploiting immunological mechanisms APC Naive T cell CD40 MHC TCR 2 4-1BB Moch 3 T cell 5 Pro-inflammatory cytokines Tumor cells 4 PD-1 PD-L1 2 Treg 5 Antibodies Healthy cells 1 B cell Pathogens 1 2 3 4 5 mRNA-encoded infectious disease vaccines mRNA-encoded cancer vaccines Shared antigens Individualized antigens Immune system CAR-, TCR-, and non- engineered cell therapies Shared antigens Individualized antigens Next-generation immunomodulators Dual agonist CPI + agonist mRNA-encoded effector molecules Antibodies Cytokines BIONTECH 16

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