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Investor Presentaiton

Strong Q3 sales performance and earnings growth¹ Q3 Worldwide Sales $16.0B +7% +8% ex-Exchange, ex-LAGEVRIO² Q3 Non-GAAP EPS3,4 Full Year Sales $59.3B +22% GUIDANCE RANGE $59.7B-$60.2B $48.7B +17% 2021 Full Year Non-GAAP EPS3 2022 2023 $2.13 +15% $5.37 $7.48 GUIDANCE RANGE $1.33 - $1.38 2021 2022 1. Results from continuing operations attributable to Merck & Co., Inc. 2. Excludes Lagevrio sales of $640 million in 3Q23 and $436 million in 3Q22. 3. Merck does not exclude expenses for upfront and milestone payments related to collaborations and licensing agreements, or charges related to pre-approval assets obtained in transactions accounted for as asset acquisitions from its non-GAAP results. YTD 2023 non-GAAP results include an aggregate $11.6 billion or $4.52 per share of R&D expenses related to the Prometheus and Imago acquisitions and upfront payment for the license and collaboration agreement with Kelun-Biotech. Full year 2022 non-GAAP results include $690 million or $0.22 of such charges. Full year 2021 non-GAAP results include $1.7 billion or $0.65 of such charges. For 2023, guidance includes an additional $5.5 billion or $1.70 per share related to the collaboration with Daiichi Sankyo, and guidance does not assume any additional significant potential business development transactions. 4. GAAP EPS of $1.86. 2023 MERCK 6
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