Benevolent Platform Precision Medicine

Target Triage: Prioritising insights and hypotheses ° 00 00 00 1. Data Preparation 2. Target Prediction 3. Target Triage 4. Target Validation Focus and curate a biological question Graph Completion Human Queries 1 2 3 4 000000 Target Safety Drugs? Metadata Score MM Tgt1 Safe Partial OPC, GCNN 0.71 Reinforcement Learning Tgt2 Unsafe No 'omics SQT 0.65 Tgt3 Safe Yes OPC, CROM 0.51 Tgt4 Phase II Offtgts OPC 0.49 Model fleet predictions Prediction evaluation Equip experts with data Triage predictions Perform Assays Analysis & retro 1. Disease Data Package 2. Predictions Package 3. Hypothesis Package 4. Validated Hypothesis Package Al Benevolent 21

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