Business Update & Financial Outlook

Accelerating our presence in immunology • • · MERCK Deep expertise in clinical trial design and execution Global clinical trial scale Proven track record of developing and implementing precision medicine strategies Emerging immunology discovery pipeline + Prometheus Biosciences • • . • Focused expertise in immunology Deep genetic and biological insights from Prometheus 360 Data Science Platform Risk-stratified biomarker approach Suite of immunology pipeline compounds MERCK 24

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