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Investor Presentaiton

Oncology Opdivo Opdualag TIGIT Bispecific DGK Inhibitor AR LDD SC administration has clear benefits for patients, HCPs, and healthcare systems HCPs and Healthcare System Logistical: Complex scheduling demands due to higher patient volume1 Resource utilization: Overlapping duties for staff, inefficient patient to nurse ratios 1,2 Patients Time burden: Inconvenience 5, opportunity cost/income loss6 Emotional burden: Loss of normality long-term survivorship and 'chronic care'7 • Reduces chair time (~5 min)³ • Allows rapid drug delivery³ . Reduces staff needed for administration³,4 • Improves healthcare resource utilization³,4 • • Reduces time in clinic³ Improves scheduling and administration 8,9,10 Improves patient QOL 3,4,11 ¹Lopez-Vivanco G. Clin Transl Oncol. 2017;19(12):1454-1461; 2Huang YL, et al. Journal of Oncology Practice. 2018; 14(2):e82-e91; 30'Shaughnessy J, et al. Eur J Cancer. 2021;152:223-232; BA. Cancer. 2008;112(11 Suppl):2556-2568. Harvey MJ, et al. Plos One. 2022;17(1):e0261336. Jonaitis L, et al. BMC Proc. 2021;15(suppl 17):25. 10 Schreiber S, et al. Adv Ther. 2022;39:2342-2364. 11Dent S, et al. Curr Oncol. 2019;26(1):e70-e80. ll Bristol Myers Squibb" "DuMond B, et al. J Oncol Pharm Prac. 2021;27(5):1214-1221. "De Cock E, et al. Cancer Med. 2016;5(3):389-397. 6Alzehr A, et al. Support Care Cancer. 2022;30(8):6385-6404. "Kim Y, Given Not for Product Promotional Use 96
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