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Investor Presentaiton

Top-tier talent Differentiated process Scalable platform Cytokinetics case study: hypertrophic cardiomyopathy (HCM) Background Cytokinetics Biotech focused on muscle biology, cardiology and neuromuscular diseases Drug pipeline in heart failure, HCM, SMA Corporate headquarters in San Francisco, California Royalty Pharma partnership in February 2017 for omecamtiv mecarbil (heart failure) Challenge What is the size of the commercial market for aficamten in HCM? Key considerations Novel disease area No FDA approved therapies Likely second to market Global market development Royalty Pharma solution Conducted detailed market evaluation • Unique Royalty Pharma capability Adds conviction to investment process 100% internal team and proprietary data Enhances engagement, value to partner Analyzed medical claims and electronic health data >150 commercial & gov't payers ~90m patient lives ~20k practices ROYALTY PHARMA SMA: Spinal Muscular Atrophy 59
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