Investor Presentation: First Nine Months of 2020

46 Investor presentation First nine months of 2020 Novo NordiskⓇ GLP-1 sourcing is primarily from outside the class but GLP-1s are still typically used after failure on other products US 'line of usage' across product classes Share of patients on OADs achieving HbA1c below 7% in major European countries GLP-1 source of business (new-to-brand prescription market share) 100% 80% 60% 40% 20% 0% Metformin SU DPP-4i SGLT-2i GLP-1 1st 2nd 3rd 4th 5th Note: Data based on data from France, Germany, the UK and the USA only OAD: Oral anti-diabetic (includes but is not limited to DPP-IV, SGLT-2, metformin and sulfonylurea) Source: IQVIA Disease Analyser (France, Germany and the UK) and IQVIA LRX (USA), Jun 2018 HbA1c >7% 43% 57% Insulin and Treatment GLP-1 naive 5% 5% Insulin 25% HbA1c <7% GLP-1 50% 11% OAD

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