Investor Presentaiton
ILT3: a key protein driving suppressive myeloid
cells activity in cancer
Immunoglobulin-like transcript 3 (ILT3) is an inhibitory immune-
receptor containing three ITIM sequences
Can be found on suppressive myeloid cells in the TME:
TAM, MDSC and DCtol
Ig domains
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ITIMS
ILT3 Receptor
Exists in membranal and soluble forms which are both active
Inhibits the effector activity of T cells and enhances the
suppressive activity of myeloid cells
Reported T cells ligands include APOE, ALCAM, PI16
BIOND
BIOLOGICS
ILT3, Ig-like transcript 3; ITIM, Intracellular tyrosine-based inhibitory motifs; TAM, Tumor-associated macrophages, MDSC, Myeloid-derived suppressor cells; Dctol,
Tolerogenic dendritic cells;
Biond Biologics Corporate Presentation | May 2021 | Non-confidential
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