American Thoracic Society - Sanofi Investor Call
Key inclusion criteria
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Aged ≥40 to ≤80 years
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BOREAS Eligibility Criteria
Physician diagnosis of moderate-to-severe COPD
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History of high exacerbation risk: ≥2 moderate or ≥1 severe exacerbation(s) within the year prior to screening
Background triple inhaler therapy (ICS+LAMA+LABA) for at least 3 months prior to randomization with a stable dose
for ≥1 month prior to screening; dual therapy (LABA + LAMA) allowed if ICS contraindicated
Self-reported signs and/or symptoms of chronic bronchitis for 3 months in the year prior to screening
Blood eosinophil count ≥300 cells/μL at the screening visit
Current or former smokers with ≥10 pack years smoking history (current smokers capped at 30%)
Key exclusion criteria
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COPD diagnosis for <12 months
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Current diagnosis or prior history of asthma
Significant pulmonary disease other than COPD
ATS 2023
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