Investor Presentation
45
Investor presentation First six months of 2022
SUSTAIN trials with subcutaneous semaglutide
1
2
3
4
5
6
7
SUSTAIN
8.1%
8.1%
8.3%
8.2%
8.4%
8.7%
8.2%
Baseline
-0.1
-0.4
Change in
HbA1c (%)
-0.5
-0.9
-0.8
-1.1*
-1.2*
-1.3*
-1.1
*
-1.3
*
-1.4*
-1.4*
-1.5
-1.5*
-1.6
-1.6*
-1.8
-1.8-1.5'
-1.6*
1.2
92 kg
89 kg
96 kg
93 kg
92 kg
92 kg
95 kg
Baseline
-1
-1.9
-1.9
-1.4
-0.7
Change in
weight (kg)
-3.7*
-4.5*
-4.3
-5.6
semaglutide 1.0 mg
-6.1*
semaglutide 0.5 mg
placebo
-3.5
-3.7*
*
-4.9
-5.2*
sitagliptin 100 mg
-6.4*
exenatide ER
glargine U100
*
-3.6
-6.5*
dulaglutide 1.5 mg
-4.6*
-3.0
-2.3
dulaglutide 0.75 mg
* Statistically significant; SUSTAIN 1: QW sema vs placebo in drug-naïve people with T2D; SUSTAIN 2: QW sema vs sitagliptin 100 mg QD in people with T2D added to 1-2 OADS; SUSTAIN 3: QW sema vs QW exenatide ER 2.0 mg in people with T2D added
to 1-2 OADS; SUSTAIN 4: QW sema vs QD insulin glargine in people with T2D added to 1-2 OADS; SUSTAIN 5: QW sema vs placebo in people with T2D added to insulin; SUSTAIN 6: QW sema vs placebo, added to standard-of-care; SUSTAIN 7: QW sema vs
QW dulaglutide 75 mg and 150 mg in people with T2D added to 1-2 OADS: ER: Extended-release; QW: once-weekly; QD: once-daily; sema: semaglutide; T2D: type 2 diabetes, OAD: oral anti-diabetics
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