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POWER: Combining Our "I" and "O" Phenotypes Gives Us Broad Statistical Power to Drive Unique Immunological Insights for Oncology Development 10 phenotypes of interest (examples) "I" Immune phenotypes Vitiligo "O" Oncology phenotypes BCC Bladder Brain Breast Colorectal Endometrial Esophageal Head and Neck Kidney' Leukemia Liver Lung Melanoma Myeloma NH lymphoma Ovarian Pancreatic Prostate SCC Stomach Thyroid Cases 410,104 15,663 4,586 118,632 25,398 17,912 1,134 8,596 14,934 13,763 3,077 12,367 125,364 7,127 17,643 13,044 2,910 71,616 218,805 3,508 27,25al: 1,133,442 Alopecia areata Hashimoto's IBD Atopic dermatitis Poison oak rash Allergy Food allergy Asthma Tonsillectomy Toenail Fungus Psoriasis Hidradenitis suppurativa Lupus Cases 60,701 56,233 186,069 116,788 716,447 783,604 2,053,011 213,185 1,128,292 270,499 276,405 277,525 31,008 58,414 Biological processes of interest captured in "I" phenotypes, not targeted in the clinic yet Autoimmunity Immune Polarization Atopy Inflammation Chronic Infection Tissue Repair Copyright © 2024 23and Me, Inc. 23and Me 7

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