Akouos IPO Presentation Deck

How We Hear Oval Window Ear Drum Round Window Membrane ("RWM") Spiral Ganglion Cells Auditory Nerve 1 Sound enters the ear through the external auditory canal of the outer ear, where it vibrates the ear drum 2 The sound vibrations are then relayed through the middle ear where they articulate with the cochlea at the oval window The cochlea contains a long, coiled, ribbon-like epithelial membrane that is suspended between two cochlear fluid compartments 4 Sensory cells, called hair cells, sense the movement of fluid and convert the fluid waves into nerve impulses that are sent along the auditory nerve to the brain CONFIDENTIAL Inner Border Cells Spiral Ganglion Cells Pillar, Cells AKOUOS Inner Hair Cells Hensen's Cells Claudius Cells Outer Hair Cells

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