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argenx SE Investor Day Presentation Deck

C2 is Ideal Point of Intervention within Complement Cascade IgG argenx (Auto)antibodies Classical C1 qrs IgM 3 Crossroad of classical & lectin pathways Manageable C2 levels in circulation Benign C2-deficiency phenotype Clearance by macrophages Membrane damage C4 C2 C3b Lectin Mannose sugar MBL MASPS C3 convertase C3 C5 convertase C5 C5b-C9 MAC C3a C5a ▬▬▬I C3a-R C5a-R Sublytic MAC Microorganisms Alternative Foreign surface C3 CFB CFD 2 Intact alternative pathway to reduce infection risk 1 Target upstream of C5 to shut down all effector functions Inflammation 51

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