RSV Seasonal Vaccine Introduction and Growth Strategy slide image

RSV Seasonal Vaccine Introduction and Growth Strategy

Continuous improvement in R&D productivity Enabled by advanced technology and partnerships R&D success rates in phase II have improved to median with phase III and registration upper quartile, three-year rolling trend 16% 14% 20% 26% 64% 81% 100% 100% 95% 95% 94% 95% End to end cycle times have improved by 20% compared to industry median since 2016 helped by vaccines performance End to end cycle times have decreased by Areas of focus 3.7 years Goal to continue to drive portfolio acceleration, improve R&D success rates, and deliver high value vaccines and medicines Doubling-down on data and platform technology, and in particular using technology to de-risk targets and progress high-quality first-in-class and best-in-class opportunities for the right patients GSK Phase II Phase III Registration 2016-2018 2017-2019 2018-2020 ■2019-2021 • Increase partnerships for new assets and capabilities Source: CMR Clarivate Analytics, 2022. Rolling three year trend 1. Industry median and top quartile values are based on major companies only (those spending ≥US$ 2 billion in 2021 on pharmaceutical R&D) 13
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