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Investor Presentaiton

Strong business momentum Diversified portfolio growth Efficient compounding engine Significant firepower to drive growth and create value Sustainable long-term growth Capacity for capital deployment over 5 years Cumulative 5-Year capacity: Capital allocation priorities Cash generated by future acquisitions (1) Incremental debt capacity to 4.0x >$20bn >$15bn >$13bn • Cash generated by existing portfolio (1) Balance sheet cash at March 31, 2022 2022e 2023e 2024e 2025e 2026e Royalty acquisitions (primary focus) Majority self-funded over time via retained cash flow Incremental debt at conservative leverage levels Strong commitment to investment grade ratings Return of capital • Current quarterly dividend of $0.19 per share • Share repurchases are an additional tool over time (2) >$2bn Primary focus of our business is creating value by acquiring royalties on innovative products ROYALTY PHARMA 1. Cash generated reflects Adjusted EBITDA less interest paid and excludes development-stage funding payments (ongoing and upfront & milestones), other previously committed funding, payments for future royalty acquisitions and return of capital. 2. Pending shareholder authorization at 2022 Annual General Meeting and subject to Board approval. 96
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