Investor Presentaiton

HPV-Associated Diseases Market Overview Years to progression HPV-associated conditions per year in US: HPV INFECTION • • 80M Americans currently infected with HPV 14M new infections annually ~7M high-risk HPV infections (HPV 16/18) LOW-GRADE DYSPLASIA • Cervical: 1.1M to 1.7M HIGH-GRADE DYSPLASIA . CANCER . . . • Cervical: ~195,000 . . Vulvar: >25,000 • Anal: >14,000 Cervical: 12,000 HPV-associated H&N: 18,000 2 Anal: 6,500 Vulvar: 4,000 - 19 Sources: US CDC (2018) HPV and Cancer, available at: https://www.cdc.gov/cancer/hpv/statistics/cases.htm (accessed July 22, 2019); Saraiya M, Unger ER, Thompson TD, Lynch CF, Hernandez BY, Lyu CW, Steinau M, Watson M, Wilkinson EJ, Hopenhayn C, Copeland G, Cozen W, Peters ES, Huang Y, Saber MS, Altekruse S, Goodman MT; HPV Typing of Cancers Workgroup. US assessment of HPV types in cancers: implications for current and 9-valent HPV vaccines. J Natl Cancer Inst. 2015 Apr 29;107(6):djv086; Inovio Pharmaceuticals, internal estimates from published data (2015-16, 2017-18); US CDC, personal communication (2015); NCI SEER Cancer Stat Facts: Cervix Uteri, Vulvar, and Anal Cancers - https://seer.cancer.gov/statfacts (accessed 2017-18); *Measured as: Genital Warts - Initial Visits to Physicians' Offices, United States, 1966-2014. Fig. 47; Schiffman M, Solomon D. Findings to date from the ASCUS-LSIL Triage Study (ALTS). Arch Pathol Lab Med. 2003 Aug;127(8):946-9; US CDC. Genital HPV Infection - Fact Sheet. INOVIO POWERING DNA MEDICINES

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