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Investor Presentaiton

Update to presentation of non-GAAP financial measures (1) Royalty acquisition Update to Adjusted Cash Flow ($ in millions) GAAP Third-party royalty (approved / development-stage) Synthetic royalty (approved) No change Non-GAAP No change 2020 Royalty Amount BCX9930 ($6) ACF (prior) $1,483 ACF (modified) $1,477 Synthetic royalty (development-stage)(2) Change (%) -0.4% 2021 No change No change Royalty BCX9930 Amount ($103) pelabresib No change Updating financials to include certain R&D funding payments ($90) CPI-0209 ACF (prior) $1,767 BCX9930, pelabresib, CPI-0209, aficamten ACF (modified) $1,573 Change (%) -11.0% Examples Approved: Cabometyx, Tremfya Development-stage: otilimab, gantenerumab Orladeyo, Nurtec incremental royalty Amounts may not add due to rounding 1. ROYALTY PHARMA 2. General treatment of development-stage funding payments - upfront and milestones in non-GAAP financials is subject to specifics of transaction; for development-stage therapies, treatment may depend on probability of success, among other factors. Ongoing R&D funding arrangements paid over time as our counterparty incurs R&D costs and already included in non-GAAP financials; upfront and milestone development-stage funding payments related to R&D funding arrangements are now included in Adjusted Cash Flow. 109
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