Q4 2021 Results slide image

Q4 2021 Results

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix 2022 events¹ (expected) NME Lead Regulatory H1 177 Lu-PSMA-617 mCRPC (US/EU) Other readouts H1 sabatolimab HR-MDS Ph2 decisions H1 alpelisib PROS (US) H1 CosentyxⓇ Lichen planus Ph2 PRELUDE H2 ScemblixⓇ 3L CML (JP/EU) H1 Cosentyx® AS IV Ph3 INVIGORATE-1 H2 tislelizumab ESCC 2L (US) H1 icenticaftor COPD Ph2b Submissions H1 H1/H2 H2 H2 H1/H2 JakaviⓇ acute & chronic GVHD (EU/JP) H1/H2 KymriahⓇ r/r follicular lymphoma (US/EU/JP) H1/H2 BeovuⓇ DME (US/EU/JP) ensovibep COVID-19 (US) H1/H2 Cosentyx® HS (EU/US) tislelizumab NSCLC (EU/US) tislelizumab 1L Nasopharyngeal cancer (US) Cosentyx® Psoriatic Arthritis IV (US) H2 UNR844 presbyopia Ph2 READER Ph3/pivotal study H1 CosentyxⓇ peripheral SpA starts H1 OAV101 SMA IT STEER H1 ensovibep COVID-19 (EMPATHY Part B) H2 JDQ443 NSCLC mono H2 ianalumab Sjögren's Syndrome H2 ianalumab Lupus Nephritis H2 ociperlimab solid tumors Submissions- H2 canakinumab NSCLC Ph3 Canopy A H2 177 Lu-PSMA-617 nmCRPC enabling H2 iptacopan PNH Ph3 APPLY-PNH H2 YTB323 2L DLBCL readouts H2 KisqaliⓇ HR+/HER2- BC (adj)2 Ph3 NATALEE H2 OAV101 SMA IT Ph3b STRENGTH H2 177 Lu-PSMA-617 MCRPC1, pre-taxane Ph3 PSMAfore 1. Selected. 2. Event driven, could move to early 2023. 19 Investor Relations | Q4 2021 Results 3 INNOVATION 1 NOVARTIS | Reimagining Medicine
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