Q4 2021 Results slide image

Q4 2021 Results

Participants Company overview Pharmaceuticals Financial performance Oncology Innovation: Pipeline overview Financial review Conclusion Appendix Innovation: Clinical trials Key milestones of pipeline assets with significant sales potential with approval by 2026 Selected assets, most advanced and key indication(s) approved by 2026 High strength of evidence Iptacopan PNH 2024 2025 2026 High strength of evidence Iptacopan C3G Iptacopan aHUS Iptacopan IgAn Remibrutinib CSU Remibrutinib MS Zolgensma SMA IT Ligelizumab CSU Ligelizumab CINDU Ligelizumab Food Allergy Kisqali YTB323 2L DLBCL lanalumab Sjögren's 2022 Ph3 readout 2023 Submission Ensovibep COVID 2022 Submission 2023 2024 2025 2026 Ph3 read/sub Scemblix Approval Ph3 readout Submission Scemblix CML 1L Ph3 readout Submission Ph3 read/sub Alpelisib PROS Approval Ph3 read/sub Piqray Ovarian Cancer Ph3 read/sub Piqray TNBC Ph3 read/sub Ph3 read/sub Ph3 readout Submission Piqray HER2+ adv BC Ph3 read/sub Ph3 data in evaluation Tislelizumab Submissions and approvals of several indications Ph3 readout Submission Ph3 read/sub Ph3 readout¹ Submission Ph3 start Ph3 read/sub Ph3 start lanalumab LN Ph3 start Cosentyx HS Submission Cosentyx Lichen Planus Ph2 readout Cosentyx AS H2H Ph3 readout Submission Cosentyx GCA Ph3 read/sub 177 Lu-PSMA-617 mCRPCR post tax Approval 177 Lu-PSMA-617 mCRPCR pre tax 177 Lu-PSMA-617 mHSPC Ph3 readout¹ Submission Ph3 read/sub NME Lead 1. Event driven, could move to early 2023. 56 Investor Relations | Q4 2021 Results Submission Moderate strength of evidence Sabatolimab MDS 2022 Ph2 readout 2023 2024 2025 2026 Sabatolimab AML Ph3 readout Ph3 readout Submission in 2022/23 Submission Ph3 read/sub NIS793 PDAC Ph3 read/sub Ph3 read/sub Pelacarsen CVRR Ph3 read/sub Canakinumab Adj. NSCLC Ph3 readout Submission Ociperlimab UNR844 Presbyopia Ph3 start Ph2 readout BeiGene option deal Submission Libvatrep COSP Ph2 readout Submission JDQ443 NSCLC JDQ443+TNO155 NSCLC Ph3 start Submission Ph3 start Submission ✓ NOVARTIS | Reimagining Medicine
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