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Investor Presentaiton

Investor Presentation First nine months of 2018 Slide 34 Million 50 North America Operations at a glance Diabetes trend in population Population with diabetes Diabetes market by value and Novo Nordisk market share Diabetes growth rate NN Insulin MS NN OAD MS bDKK 400 Novo Nordisk reported sales NN GLP-1 MS First nine months of 2018 Sales (mDKK) growth² YTD 80% 40 18% 40 230% Long-acting insulin³ Premix insulin4 9,455 (9%) 1,061 (16%) GLP-1 300 60% Fast-acting insulin5 7,389 (9%) 39 38.0%¹ Human insulin 1,485 13% 30 33 200 40% Total insulin 19,390 (8%) 20 10 20 GLP-16 13,971 18% 18.2%¹ Insulin 100 20% 10 Other diabetes care? Diabetes care 638 0% 33,999 1% 10 22.3%¹ OAD Obesity (SaxendaⓇ) 1,825 31% 0 0 0% Biopharm³ 5,234 (8%) 2000 2017 2045 Aug 2013 Aug 2018 Total 41,058 1% North America Population 2018: ~0.4 billion people and diabetes prevalence 11% Source: International Diabetes Federation: Diabetes Atlas 1th Edition 2000 and Diabetes Atlas 8th Edition 2017 1 CAGR calculated for 5-year period Competitor value market share for insulin as of Aug 2018: Eli Lilly 30% and Sanofi 27% Competitor value market share for GLP-1 as of Aug 2018: Eli Lilly 41% and AstraZeneca 13% OAD: Oral anti-diabetic; MS: Market share Source: IQVIA MAT Aug, 2018 value figures 2 Percentage change in local currency from YTD Q3 2017 to YTD Q3 2018 3 Comprises Tresiba®, XultophyⓇ and LevemirⓇ; 4 Comprises NovoMix®; 5 Comprises FiaspⓇ and NovoRapid®; 6 Comprises VictozaⓇ and OzempicⓇ; 7 Comprises NovoNorm® and needles; 8 Comprises primarily NovoSeven®, NovoEight® NovoThirteen®, Refixia®, Norditropin®, Vagifem® and Activelle®
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