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Investor Presentaiton

Company overview Financial performance Oncology Immunology Financial review 2022 priorities Appendix Innovation: Pipeline overview Innovation: Clinical trials Ophthalmology Neuroscience Respiratory Disease JDQ443-KRAS inhibitor NCT05132075 KontRASt-02 (CJDQ443B12301) Indication Non-small cell lung cancer, 2/3L Phase Phase 3 Patients 360 Primary Outcome Measures Arms Progression free survival (PFS) Intervention Target Patients Read-out Milestone(s) Arm 1 Experimental: JDQ443 Arm 2 Active Comparator: Participant will be treated with docetaxel following local guidelines as per standard of care and product labels Patients with advanced non-small cell lung cancer (NSCLC) harboring a KRAS G12C mutation who have been previously treated with a platinum- based chemotherapy and immune checkpoint inhibitor therapy either in sequence or in combination. 2024 Publication NA References Abbreviations Cardio-Renal Global Health Biosimilars 51 Investor Relations | Q2 2022 Results NOVARTIS | Reimagining Medicine
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