Valneva IPO Presentation Deck

Immunogenicity Summary - Cellular Response Induced Exploratory endpoints evaluated T-cell responses by IFNgamma ELISpot analysis against S-protein, Membrane-protein and Nucleocapsid-protein. At Day 36, in the high dose group: ■76% of study participants (34/45) were reactive 1 against peptide pools spanning the full-length S- protein 36% (16/45) against the M-protein 49% (22/45) against the N-protein S-protein ■ Reactive Non-reactive M-protein Reactive Non-reactive N-protein V Reactive Non-reactive ¹Sample is considered reactive against individual stimulation panel (peptide pools) if normalized spot counts (Nil control counts substracted) per 2.10 x 10^5 PBMCs 26 Valneva - Roadshow Presentation April 2021 31

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