Investor Presentation Full Year 2017
Investor Presentation
Full year 2017
Slide 81
Obesity is a chronic disease that requires treatment
The set-point theory portrays how metabolic
changes affect the ability to lose weight
Weight gain
Set-
point
Increased appetite
and slowing of
metabolism
Diet and exercise to
reduce weight
•
The body fights weight loss for
people with obesity
The body "remembers" its highest body weight and defends
this body weight as the "new normal weight"
• During weight loss, changes occur in appetite-regulating
hormones, which increase hunger
•
New
New
set-
point
set-
point
Hormone levels signal
change to keep weight
up
If people with obesity do not eat enough, the hormones
trigger the body to conserve energy
• Changes in hormones persist for at least 5-10 years
following weight loss
changing
diabetes®
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