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Investor Presentaiton

Company overview Financial review 2022 priorities Appendix References CosentyxⓇ double digit demand-driven growth in Q2 Sales evolution USD m, % cc Ex-US US 1,175 +12% 1,275 539 460 715 736 Q2 2021 Q2 2022 1 GROWTH Cosentyx E AZ K KL Maintaining double-digit growth outlook for FY2022 Steady volume growth across US, EU and China Confidence in clinical profile; >700k patients across 5 indications GRAPPA PSA guidelines highlight Cosentyx unique benefit in axial manifestations and proven efficacy of IL17 across all 6 domains¹ Confident in USD 7bn+ peak sales Continued demand-led growth WW Life cycle management - Q2 progress: - JPSA/ ERA pediatric approvals in EU - HS submitted in EU, US anticipated H2 - axSpA IV study (INVIGORATE 2) positive readout - PSA IV US submission anticipated H2 WW Worldwide HS - Hidradenitis Suppurativa JPSA - Juvenile Psoriatic Arthritis ERA - Enthesitis related arthritis PSA - Psoriatic Arthritis axSpA - axial Spondyloarthritis Assessment of Psoriasis and Psoriatic Arthritis 1. Coates et al. Nat Rev Rheumatol (2022) IV Intra venous GRAPPA - Group for Research and 8 Investor Relations | Q2 2022 Results ✓ NOVARTIS | Reimagining Medicine
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