Investor Presentaiton
OPK titers
Positive pre-clinical data support move to phase 1/2 in 2023
sanofi
mRNA expression of bacterial antigens induces functional
immune responses at least equivalent to recombinant proteins
No interference in induced responses with
combination of all three mRNAs
Antigen 1
Antigen 2
107
107
106
105
104
103
OPK titers
106
105
104
Seroneutralization titers
103
1
rProt
mRNA Negative
rProt mRNA Negative
control
control
OPK: opsonophagocytic killing
109 Vaccines Investor Event
Antigen 3
100
107
10
rProt mRNA Negative
control
Neutralization of
inflammatory factor
OPK titers
106
105
104
Seroneutralization titers
100
10
10
103
1
1
2
mRNA mRNA mRNA Negative
Antigen Antigen Antigens control
1+2+3
mRNA mRNA Negative
Antigen Antigens control
3
OPK: opsonophagocytic killing
1+2+3
Neutralization of
inflammatory factorView entire presentation