Investor Presentation Q1 2023

111 Investor presentation First three months of 2023 Insulin market size and volume market share in EMEA Insulin market share and market size (DKK billion) Total 48% Long- acting 41% Fast- 55% 12 acting 74% Premix 3 20 20 43% Human 3 Novo Nordisk Competitors Market growth A Market share 60% 37 1.2% -0.1% 3.8% +1.0% 40% EMEA Insulin volume: Market share 10% 47% 7% 4% -2% 2.0% -0.9% 1% 20% -7.0% 0.0% 0% Feb 2020 NN market share -8.9% -1.0% Source: IQVIA, Feb 20223 LHS graph - Value, RHS Graph - Volume, MAT, Europe, Middle East & Africa, Share of growth not depicted due to too high numbers; NN: Novo Nordisk -2% -2% -5% Feb 2023 Market growth (right axis) -NN growth (right axis)

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